Selective Electrosynthetic Hydrocarboxylation of α,β-Unsaturated Esters with Carbon Dioxide
01-03-2022 12:48
Electrosynthetic hydrocarboxylation of α,β-unsaturated olefins with excellent regioselectivity is reported. The method requires no sacrificial electrode and is thus amenable to a flow configuration. The products are purified by simple crystallization. The synthesis of a precursor to ethosuximide, which contains an all-carbon quaternary center, illustrates the potential of the process. Finally, a robustness study has benchmarked the process for future users.