Hepato-toxic risk of gum arabic during adenine-induced renal toxicity prevention
Material and Methods: Rats were divided into four groups treated for consecutive 28 days. Control group was given normal food and water. GA group was given GA (15% w/v/day) in drinking water. AD group; received AD (50 mg/kg/day, intraperitoneally). GA+ AD group received both AD (50 mg/kg/day) and GA (15% w/v/day). On day 29, rats were sacrificed and serum creatinine, urea, uric acid, blood urea nitrogen (BUN), aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin, bilirubin, cholesterol levels, and renal/hepatic malondialdehyde (MDA), superoxide dismutase (SOD), and catalase were estimated. Kidney/liver histo-pathological studies were performed. Results: GA supplement efficiency in preventing AD-induced renal toxicity is clearly evident from histo-pathological examination and reduced urea, BUN, and creatinine levels. Also, it is proven that GA supplementation produces harmful effects on the liver as it increases ALT and AST levels. Conclusion: Liver function tests should be monitored in chronic kidney disease (CKD) patients who utilize GA supplement