Follow-up the Human Umblical Cord Stem Cell Injected Into Rats with renal Impairment

Umbilical cord (UC) is a source of a population of pluripotent, mesenchymal-like stem cells, UC is
rapidly gaining attention for its therapeutic value their lowincidence of rejection after UCtransplantation. UC
transplantation does not require perfect antigen matching. The aim of this study to follow-up human Umblical Cord
Stem Cell injected Into Rats With renal Impairment by biochemical and histochemicalparameters and show the
effect ofmesenchymal stem cell (MSC) on kidney generation.After cells isolation and then they were cultured in
optimum growth media. Twenty four albino male rats used in this study, Sixteen rats were injected with cisplatin
drug (5 mg /kg body weight) single dose to obtain rats with acute renal failure, then they were divided into two
groups, group I: contains eight rats with a cute renal failure as a positive control, group II: contains eight rats were
injected with a mesenchymal stem cell (MSC) (100 μl of cell suspension (1x106 cell) intraperitoneally injected
single dose.GroupIII: containeightrats were intraperitoneally injected with saline solution (100 μl /kg body weight).
Biochemical and hisochemical studies to show significantly (p<0.05) renal tissue recovery. This work showed that
these cells have the therapeutic potential for cell therapy and biological treatment which can be easily obtained.
[Salem A. Habib, Mahmoud H. Sayed and Rana R. El-Sadda. Follow-up the Human Umblical Cord Stem Cell
Injected Into Rats with renal Impairment.