Diagnostic Value of Serum Adenosine Deaminase in Type II Saudi Diabetic Patients

Background: Diabetes mellitus (DM) is one of the most causative
important factors of mortality in the developing countries. Adenosine
deaminase (ADA) is a purine metabolizing enzyme that catalyzes
the deamination of adenosine to inosine. The aim of the work was
to evaluate the diagnostic value of serum ADA and its association
with hyperglycemia in type II Saudi diabetic patients in Tabuk region
at Kingdom of Saudi Arabia. Seventy one Type II Saudi diabetic
patients and twenty two healthy controls were enrolled in this study.
The diabetic patients were divided into four groups according to
their fasting blood sugar. Serum levels of ADA, total cholesterol (TC),
triglycerides (TG), glycosylated hemoglobin (HbA1c), alanine amino
transferase (ALT), aspartate amino transferase (AST), urea, creatinine,
uric acid, Malondialdhyde (MDA), Glutathione Peroxidase (GPx) and
Superoxide dismutase (SOD) were measured.
Results: There was a significant increase (p < 0.05) in serum
ADA, TC, TG, HbA1c, ALT, AST, urea, creatinine, uric acid and MDA
in diabetic groups compared to the controls, while the levels of GPx
and SOD were significantly decreased (p < 0.05) in diabetic groups
compared to the controls.
Conclusion: The increasing of serum activity of adenosine
deaminase was found as a good diagnostic marker for type II Saudi
diabetes where it is highly significantly correlated with the glycemic
status