A new cytotoxic brominated acetylenic hydrocarbon from the marine sponge Haliclona sp. with a selective effect against human breast cancer

hree acetylenic brominated derivatives were isolated from a Red Sea sponge, Haliclona 
sp. One of them, 18-bromooctadeca-9 (E), 17 (E)-dien-7, 15-diynoic acid (3), is a known 
metabolite, and the other two are new compounds,(1E, 5E, 12E, 19E)-1, 22-dibromodocosa-
1, 5, 12, 19-tetraen-3, 14, 21-triyne (1) and methyl 18-bromooctadeca-9 (E), 17 (E)-dien-7, 
15-diynoate (2) which was isolated for the first time as a natural metabolite. Structures of all 
compounds were determined based on extensive spectroscopic measurements [1D (1H, ...