Oligodeoxynucleotides containing 2′-amino-LNA nucleotides as constrained morpholino phosphoramidate and phosphorodiamidate monomers

Incorporation in a 2′→ 5′ direction of a phosphorodiamidite 2′-amino-LNA-T 
nucleotide as the morpholino phosphoramidate and N, N-dimethylamino 
phosphorodiamidate monomers into six oligonucleotides is reported. Thermal denaturation 
studies showed that the novel 2′-amino-LNA-based morpholino monomers exert a 
destabilizing effects on duplexes formed with complementary DNA and RNA.