Molecular docking, potentiometric and thermodynamic studies of azo rhodanines

Molecular docking was used to predict the binding between azo rhodanine 
derivatives (HL n) with the receptor prostate cancer 2Q7K hormone. The values of 
dissociation constant (pK H) of azo rhodanine derivatives (HL n) are correlated with 
Hammett_s constant (σ R). The proton-ligand dissociation constant of azo rhodanine 
derivatives (HL n) and metal-ligand stability constants of their complexes with metal ions (Mn 
2+, Co 2+, Ni 2+ and Cu 2+) have been determined potentiometrically in 0.1 M KCl