New Potentiometric Screen-printed Sensors for Determination of Trimebutine Drug in Tablets, Serum and Urine Samples

A new sensit4e and select4e modified screen printed electrodes (MSPEs) and carbon paste electrodes (MCPEs) were studied in order to determine trimbutine maleate (TM) in pure, tablets, urine, and serum samples. These sensors were embodied with multiwalled carbon nanotubes (MWCNTs) since it improved the quality of the sensors in presence of potassium tetrakis (p-chlorophenyl) borate (KTpClPB) ionophore. A good Nernstian response for the constructed sensors, at optimum paste composition, was exhibited for determination of TM in concentration range of 1.5× 10-7-1.0× 10-2 and 1.0× 10-7-1.0× 10-2 mol L-1 at 25 C with detection limit of 1.5× 10-7 and 1.0× 10-7 mol L-1 for MCPE and MSPE, respect4ely. It seemed that the potential of the electrodes was independent on pH in the range of 2.0-8.0, 2.0-8.5, 2.0-8.