Structural, molecular docking computational studies and in-vitro evidence for antibacterial activity of mixed ligand complexes
A novel bis-bidentate azo dye ligand, formed by the diazotized reaction of 1,4-diaminobenzene and 8- hydroxyquinoline in 1:2 M ratio resulted the formation of 5,5′-{(1E, 1E`)-1,4-phenylenebis(diazene-2,1-diyl)}bis(quinoline-8-ol) (H2L1) as primary ligand and its Cu(II), Ni(II), Co(II), Mn(II), Cr(III), UO2(II) and Cd(II) complexes. Incorporating of 8-hydroxyquinoline (HL2) as co-ligand with the formed mixed-ligand complexes of the composition, [M2(L1)(L2)2(OH2)4] (M = Cu(II), Co(II), Ni(II), Mn(II), UO2(II), Cd(II) and [Cr2(L1)(L2)2(OH2)2(Cl2)] were synthesized and characterized. H2L1, HL2, and their mixed ligand complexes were screened against two local gram-positive bacteria (Staphylococcus aureus and Bacillus cereus) and three local gram-negative bacteria (Klebsiella pneumoniae Escherichia coli and Pseudomonas sp).