Synthesis, theoretical study, molecular docking and biological activity of nano tridentate (E)-2-((3-hydoxyphenyl) methyl) phenol metal complexes

A new series of transition metal complexes of Schiff base (E)-2-((3-hydoxyphenyl)methyl)phenol (H₂L) with Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) have been synthesized and characterized using elemental analysis, IR, UV–Vis spectra, mass spectra, reflectance spectra, molar conductance measurements, magnetic susceptibility measurements, ¹H NMR spectroscopy, thermal and X-ray diffraction analyses. The infrared spectral data showed that the chelation of the ligand towards transition metal ions occurs through two deprotonated phenolic oxygen atoms and azomethine nitrogen (ONO) in binegative tridentate manner. The XRD patterns of the complexes have sharp diffraction peaks indicating that these complexes are a mixture of crystalline and amorphous phases.