Electrochemical Study of the Interaction of the Alkylating Agent Busulfan with Double Strand DNA

 Damage of salmon sperm double strand ss dsDNA in solution or immobilized on 
screen-printed carbon electrode (SPCE) induced by incubation of DNA with the 
antineoplastic alkylating agent busulfan (BUS) at various conditions was detected for the first 
time by simple electrochemical methods. Chemical changes in DNA bases can be detected 
through the altered electroactivity of the DNA. Electrochemical voltammetric sensing of 
damage caused by BUS to dsDNA in solution was monitored by the appearance of peaks ...