Adipocytokines in Patients with Chronic Kidney Disease Stage 5

Background:

Chronic kidney disease (CKD) leading to kidney failure and end stage renal disease (ESRD) is a

common health problem associated with wasting syndrome characterized by inadequate nutrient intake and decrease

tissue anabolism and/or catabolism. In CKD adipokines, especially leptin and adiponectin (ADPN), accumulate

in serum due to reduced renal clearance. Although, rapidly growing, knowledge of adipocytokines is limited

and much is still unknown of the altered adipocytokine pattern in patients with impaired renal function. The

aim of this study is to assess the adipocytokines, leptin, and adiponectin in relation to weight loss in pediatric patients

with CKD stage-5 treated conservatively (CT) or undergoing maintenance hemodialysis (MHD).