Polymer complexes. LXXV. Characterization of quinoline derivative polymer complexes as potential bio-active and anti-corrosion agents

The Cu²⁺, Co²⁺, Ni²⁺ and UO₂²⁺ polymer complexes of 5-(2,3-dimethyl-1-phenylpyrazol-5-one azo)-8-hydroxyquinoline (HL) ligand were prepared and characterized. Elemental analyses, thermogravimetric analyses, spectroscopic and X-ray diffraction analysis and thermal analysis studies have been used to confirm the structural of the prepared polymer complexes. The chemical structure of metal chelates commensurate that the ligand act as neutral bis(bidentate) by through four sites of coordination (azo dye nitrogen, carbonyl oxygen, phenolic oxygen and hetero nitrogen from pyridine ring). The molecular and electronic structure of the hydrogen bond conformers of HL ligand were optimized theoretically and the quantum chemical parameters were calculated. Elemental analysis data show that the polymer complexes have composition of octahedral geometry for all the polymer complexes. Molecular docking of the binding between HL and the receptors of prostate cancer (PDB code 2Q7L Hormone) and the breast cancer (PDB code 1JNX Gene regulation) was studied. The interaction between HL and its polymer complexes with the calf thymus DNA (CT-DNA) was determined by absorption spectra. The antimicrobial activity of HLand its Cu²⁺, Co²⁺, Ni²⁺ and UO₂²⁺ polymer complexes were investigated; only Cu(II) polymercomplex (1) was specifically active against Aspergillus niger. It inhibited the fungal sporulation and distorted the fungal mycelia, which became squashed at a concentration of 150 μg/ml; Transmittance electron microscope (TEM) also showed a deactivation of autophagy in the treated A. niger cells via accumulation of autophagic bodies in vacuoles. The inhibition process ofthe prepared ligand (HL) against the corrosion of carbon steel in HCl (2 M) solution was determined by various methods are found to be in reasonable agreement. The mechanism of inhibition in presence of HL in carbon steel corrosion obeys Friendlish adsorption isotherm.

Cu²⁺, Co²⁺, Ni²⁺ and UO₂²⁺