The aim of the present study is to investigate the protective effects of curcumin and/or ginger against carbon tetrachloride (CCl₄) induced hepatotoxicity. Therefore, 45 rats were divided into 5 groups each of 9 rats. Control group, CCl₄ group: Injected i/p with CCl₄ (0.5 mL kg^–1 b.wt.) mixed (v/v) in olive oil, curcumin group: Injected i/p with CCl₄and treated with curcumin (200 mg kg^–1 b.wt.), ginger group: Injected i/p with CCl₄ and treated with ginger (100 mg kg^–1 b.wt.) and ginger and curcumin group: Injected i/p with CCl₄ and treated with a mixture of curcumin and ginger (100 and 50 mg kg ^–1, respectively). After 8 weeks from the start of the experiment, blood samples and liver tissues were collected for biochemical and histopathological analysis, respectively. The present study revealed that, CCl₄ elevated liver enzymes activities (ALT and AST) and increase malondialdehyde (MDA) level. On the other hand, CCl₄ …