Synthesis, cytotoxicity assessment and antioxidant activity of some new thiazol-2-yl carboxamides

Dependence on the biological activity of 2-aminothiazole, the synthesis and
chemical reactions of ethyl 3-oxo-3-(thiazol-2-ylamino)propanoate (1) with
some different reagents were described for cytotoxic and antioxidant evaluation.
The new derivatives 2–19 could be synthesized and characterized by correct
analytical and spectral data. In addition to the thiazole ring, these
compounds contain 2H-1,2,3-triazole (3), 1H-pyrazole (5, 12), 1,3-dithiane (7),
benzothiazole (10), thiazolidine (13), thiazolidinone (14, 15), 2H-chromene
(17), pyridine (19) moieties. The preparation of compounds 2–19 was performed
through the formation of the isolable 2-(2-phenylhydrazineylidene) 2,
2-dimethylaminomethylidene 4, 2-phenylcarbamothioyl 9, 2-(methylthio)
(phenylamino) methylidene 11 and non-isolable potassium bis(thiolate) 6,
potassium thiolate 8 intermediates from precursor 1. The activity of these
derivatives 1–19 against human lung fibroblast (WI38) and human prostate
cancer (PC3) were examined in vitro using the MTT assay. The assessment of
their antioxidant activities was carried out by following the ABTS method to
evaluate their pharmaceutical importance.