New Synthetic Flavonoid with in vitro Antitumor Activity

Flavonoids have a wide spectrum of biological activities like antioxidant, anti-inflammatory, antitumor, etc. In this work a novel synthetic flavonoid ‘’ethyl 2-amino-4-phenyl-4H-benzo(h)chromene-3-carboxylate’’ was synthesized, characterized, and then investigated in vitro for potential antitumor activity in compare to that of the well established antitumor natural flavonoid ‘’quercetin’’. The new compound displayed potent antiproliferative action against human prostate cancer (PC3) and human hepatoma (HEPG2) cells. It can be concluded that the new synthetic flavonoid have in vitro optimistic antitumor activity