Development of New Potential Anticancer Metal Complexes Derived from 2-Hydrazinobenzothiazole

Background: Due to the side effects of clinically approved anticancer drugs there is a great
need to explore and develop new metal-based anticancer drug molecules of high efficiency with less or no
side effects.
Objective: To synthesize new metal complexes of 2-hydrazinobenzothiazole (hbt) and to investigate their
potential anticancer characteristics.
Method: New five complexes; [VO(hbt)2SO4].4H2O (1), [Ru(hbt)2Cl3(H2O)] (2), [M(hbt)2Cl2] [M(II) =
Pd (3), Pt (4)] and [Ag(hbt)2].NO3 (5) were prepared and their structure was investigated by means of FTIR,
1H NMR, ESI-MS and UV-Vis spectra, elemental and thermal analysis, magnetic and molar
conductance measurements. The ligand and its complexes were examined as anticancer agents against
Ehrlich ascites carcinoma (EAC) and human cancer cells (hepatocellular carcinoma Hep-G2,
mammary gland breast cancer MCF-7 and colorectal carcinoma HCT-116).
Results: This feature is further supported by the DNA-metal complexes binding ability. In addition,
anti-oxidation activity of the complexes was investigated.
Conclusion: Complex (5) showed the highest antioxidation and anticancer activities.