Genetic polymorphisms of TP53 Arg72Pro and Pro47Ser among Egyptian patients with colorectal carcinoma

Previous reports demonstrated the role of TP53 gene polymorphisms with CRC
risk among several ethnic populations. The purpose of this study is to assess the association
of the TP53 Arg72Pro and Pro47Ser variants with CRC risk among Egyptian patients.
Subjects and Methods: This work was conducted on 120 unrelated CRC Egyptian patients
who were compared to 140 healthy controls. DNA was genotyped for these variants using
the PCR-RFLP technique. Results: CRC patients observed a significant association of the
rare genotype of TP53 Arg72Pro polymorphism compared with healthy controls. On the
contrast, all genetic models showed no statistical association of TP53 Pro47Ser
polymorphism among CRC patients compared with healthy controls. On the contrast, CRC
patients of the TP53 gene polymorphisms indicated no significant difference regarding